Breakage of a DNA-protein complex induced by bleomycin and their repair in cultured mouse fibroblasts.
نویسندگان
چکیده
The effect of bleomycin on DNA strand breakage and its repair in cultured mouse fibroblast strain L-P3 (a substrain of L929) was studied. Treatment of L-P3 cells with bleomycin caused single-strand breaks of DNA as revealed by alkaline sucrose gradient centrifugation. The singlestrand breaks of DNA were rejoined within 3 hr when the treated cells were incubated at 37°in a medium free of the antibiotic ("recovery incubation"). Analysis by neutral
منابع مشابه
Single-strand scission and repair of DNA in mammalian cells by bleomycin.
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ورودعنوان ژورنال:
- Cancer research
دوره 33 7 شماره
صفحات -
تاریخ انتشار 1973